Fall 2019 Courses
Organic Chemistry II
Research in Biological Chemistry
There are several projects ongoing in the lab, all of which involve designing and synthesizing molecules to elucidate or control biological systems. Undergraduate students learn various techniques including organic synthesis, PCR and cloning, protein purification, and enzymology.
Our lab is supported by a grant from the National Institutes of Health.
Budin N, Higgins EH, DiBernardo A, Raab C, Li C, Ulrich SM. "Efficient synthesis of the ketone body ester (R)-3-hydroxybutyryl-(R)-3-hydroxybutyrate and its (S,S) enantiomer" Bioorganic Chemistry Volume 80, October 2018, Pages 560-564 link
Stalnecker CA, Ulrich SM, Li Y, Ramachandran S, McBrayer MK, DeBerardinis RJ, Cerione RA, Erickson JW. "Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells." Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):394-9.
Shimazu T, Hirschey MD, Newman J, He W, Shirakawa K, Le Moan N, Grueter CA, Lim H, Saunders LR, Stevens RD, Newgard CB, Farese RV Jr, de Cabo R, Ulrich S, Akassoglou K, Verdin E. "Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor." Science. 2013 Jan 11;339(6116):211-4 link
Swem L, Swem D, O'Loughlin C*, Gatmaitman R*, Ulrich SM, Bassler B. A Quorum Sensing Antagonist that Targets Both Membrane-Bound and Cytoplasmic Receptors Controls Bacterial Pathogenicity Molecular Cell 35 (2) 143-153, 31 July 2009 link
KrennHrubec K, Marshal B, Hedglin M, Verdin E and Ulrich SM. "Design and Evaluation of Linkerless Hydroxamic Acids and Selective HDAC8 Inhibitors" 2007 March 30 Bioorganic and Medicinal Chemistry Letters link