Spring 2017 Courses
Biochemistry and Molecular Biology: BIOC 333
Organic Chemistry II: CHEM 221
I began studying chemistry at Temple University and had my first research experience in the lab of Grant Krow. There, I worked on a hetero-Diels Alder reaction and regioselective alkene functionalization towards the synthesis of homo-epibatidine. After Temple, I began graduate work at Princeton in the lab of Kevan Shokat. There I did work on protein engineering to alter the nucleotide triphosphate substrate preference of protein tyrosine kinases to identify their downstream signaling partners as well as the design and synthesis of selective histone deacetylase inhibitors.
Research in Biological Chemistry
There are several projects ongoing in the lab, all of which involve using chemistry to elucidate or control biological systems. Undergraduate students in my lab often learn various techniques such as organic synthesis, protein expression/purification and enzymology.
Stalnecker CA, Ulrich SM, Li Y, Ramachandran S, McBrayer MK, DeBerardinis RJ, Cerione RA, Erickson JW. "Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells." Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):394-9.
Lehmann M, Hoffmann MJ, Koch A, Ulrich SM, Schulz WA, Niegisch G. "Histone deacetylase 8 is deregulated in urothelial cancer but not a target for efficient treatment." J Exp Clin Cancer Res. 2014 Jul 10;33(1):59
Chen A, Karolczak-Bayatti M, Sweeney M, Treumann A, Morrissey K, Ulrich SM, Europe-Finner GN, Taggart MJ. Lysine deacetylase inhibition promotes relaxation of arterial tone and C-terminal acetylation of HSPB6 (Hsp20) in vascular smooth muscle cells. Physiol Rep. 2013 Nov;1(6) link
Shimazu T, Hirschey MD, Newman J, He W, Shirakawa K, Le Moan N, Grueter CA, Lim H, Saunders LR, Stevens RD, Newgard CB, Farese RV Jr, de Cabo R, Ulrich S, Akassoglou K, Verdin E. "Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor." Science. 2013 Jan 11;339(6116):211-4 link
Magadalena Karolczak-Bayatti, Michele Sweeney, Joanna Cheng, Lydia Edey, Stephen C. Robson, Scott M. Ulrich, Achim Treumann, Michael J. Taggart, and G. Nicholas Europe-Finner "Acetylation of heat shock protein 20 (Hsp20) regulates human myometrial activity" J. Biol. Chem. 2011 doi: 10.1074/jbc.M111.278549 link
Tao Su, David M. Bryant, Frédéric Luton, Marcel Vergés, Scott M. Ulrich, Kirk C. Hansen, Anirban Datta, Dennis J. Eastburn, Alma L. Burlingame, Kevan M. Shokat Keith E. Mostov "A kinase cascade leading to Rab11-FIP5 controls transcytosis of the polymeric immunoglobulin receptor" Nature Cell Biology 2010 DOI: doi:10.1038/ncb2118
Swem L, Swem D, O'Loughlin C*, Gatmaitman R*, Ulrich SM, Bassler B. A Quorum Sensing Antagonist that Targets Both Membrane-Bound and Cytoplasmic Receptors Controls Bacterial Pathogenicity Molecular Cell 35 (2) 143-153, 31 July 2009 link
Oehme I, Deubzer HE, Wegener D, Pickert D, Linke J, Hero B, Kopp-Schneider A, Westermann F, Ulrich SM, von Deimling A, Fischer M, and Olaf Witt. "Histone Deacetylase 8 in NeuroblastomaTumorigenesis" Clinical Cancer Research 91 15(1) January 1, 2009 link
Ulrich SM "Chemistry and Roles of Protein Kinases and Dephosphorylases" 2007 Wiley Encyclopedia of Chemical Biology link
KrennHrubec K*, Marshal B, Hedglin M*, Verdin E and Ulrich SM. "Design and Evaluation of Linkerless Hydroxamic Acids and Selective HDAC8 Inhibitors" 2007 March 30 Bioorganic and Medicinal Chemistry Letters link