We use the small nematode worm Caenorhabditis elegans to identify some of the biochemical pathways, and individual genes, that mediate the genotype-phenotype relationship in the presence of Bisphenol A, a chemical that is used as a plasticizer in food containers. We use Microarray technology and RNAi screens to compare exposed to unexposed individuals, and identify crucial pathways and genes whose level of expression is modified as a result of exposure to BPA. Then we focus on some of the genes identified and compare their expression across different C. elegans genotypes in order to study gene by environment interactions that affect the organism’s reaction to exposure to Bisphenol A.
~~~~~~~
I am also a faculty member in the Biochemistry program.
